Research and Collaborations

We also undertake research collaboration for various projects;

Mutation study of the prevalent Lysosomal storage disorders in India and extension of Lysosomal enzyme study in western India Indian Council of Medical Research [2009-2012]

“Preparation and Standardization of FISH probes for various genetic disorders & extension of services in Gujarat.” DBT : 2008 – 2011
"Study of Lysosomal storage Disorders in children with Regression of milestone"
Indian Council Of Medical Research [Jan 2007- Dec- 2009]

"Study of Genetic Susceptibility to Neural Tube Defect and its association with maternal vitamin B-12 and Folate status."
Department Of Biotechnology [Jan 2007- Dec- 2009]
"Herbal Drug Preparation and characterization for type II Diabetes"
Multicentre project of CSIR-NMITLI Project. Govt Of India.
" Prostate Neoplasm: PSA, IGF1, Free PSA and PSA density in early identification of neoplastic process"
GUJCOST, Govt. of Gujarat.
"Linkage study of Clouston Syndrome (Hydrotic Ectodermal dysplasia) mapped to #13q."
Univ. Of Geneva, The Medical School Cantonal Hosp. Geneva, Switzerland.
"Gene Polymorphism and Folate Metabolism in mothers with Down syndrome child."
Toxicological Research centre, Arkansas, USA
"Study of LAMIN gene mutation in large Indian Family with Familial Partial Lipodystrophy"
Bharatiya Vidya Bhavan's SPARC, Mumbai and Prof Robert Hegle,
Canada.
"Revaluation of the traditional production of the hybrid of the Indian wild ass (Equus hemionus khur) and the female donkey (E. asinus) in Gujarat, India. The study of Karyotype in hybrid of the Indian wild ass."
Aquine Musium, Japan.

Lysosomal storage disorders:
Though individually these are rare, collectively the incidences are approximately 1 : 5000. At FRIGE we are carrying out 22 different lysosomal enzymes. We are now focusing on identifying mutations for Gaucher, NPD and Morquio Disease and awaiting grant from ICMR.

For more you can click on Lysosomal Disorders.
Genotyping and Nutritional factors responsible for Neural Tube Defects:
With the help of 3D sonography and AFP marker, hardly any NTD’s can be missed and opt for abortion. It has been shown about the incidences of 1 in 1000 to as high as 3 in 1000. Under the multicentric project of DBT, FRIGE together with CCMB, KEM Hospital (Pune), FCRF (Chennai) is now involved in this national study for possible prevention of NTD’s in future.
Genotoxicity prevention in Type II Diabetes:
As a part of CSIR – NMITLI project, currently the Centre is involved in various DNA damage and repairs activity study. This include study ofsister chromotid exchanges, COMET assay, 8-OHdg study and protein oxidation study.

Fig: COMET of Type II Diabetic patient
Our group is actively involved in the project on “Preparation & Characterization of FISH probes utilizing BAC sequence. And now we are also focusing on CGH Array study in Children with multiple congenital anomalies and IUGR Pregnancies.